![]() Some aspects of the haemoglobinopathies of particular relevance to Saudi Arabia and other parts of the Middle East. Sheikha Al Arrayed ,Eastern Mediterranean Health Journal | Volume 1,1995 *Weatherall DJ. In Qateef region of Saudi Arabia Hb F found at steady high level in sickle cell disease has been the rule rather than exception*. It was also found that their haematological values are similar to those of patients from Eastern Province, Saudi Arabia, where the mild form of the disease predominates. įeatures of sickle-cell disease in Bahrain In 56198 Bahrainis, we found that 2% of newborns have sickle-cell disease (SCD) and 18% have sickle-cell trait, while 24% are carriers of the (thalassaemia gene). India The prevalence has ranged from 9.4 to 22.2% in endemic areas. Middle East About 6,000 children are born annually with SCD, at least 50% of these in Saudi Arabia. WHO report 2% of newborns affected by sickle cell anemia The carrier 2% and 40% United Kingdom In United Kingdom, more than 200 babies are born annually with SCD. Africa Three quarters of sickle-cell cases occur in Africa. Sickle Cell Trait Sickle haemoglobin (S) + Normal haemoglobin (A) in RBC Adequate amount of normal Hb (A) in red blood cells RBC remain flexible Carrier Do Not have the symptoms of the sickle cell disorders, with exceptions: Pain when Less Oxygen than usual (scuba diving, activities at high altitude (12,000ft), under general anaesthesia) Minute kidney problems* *Gupta, Kirchner, Nicholson, Adams, Schechter, Noguchi, Steinberg, JCI 1991Įpidemiology The highest frequency of sickle cell disease is found in tropical regions, particularly sub-Saharan Africa, India and the Middle-East. ![]() ![]() Haemoglobin A two alpha two beta A2 two alpha two delta F two alpha two gammaĬ ommon types of Sickle Cell Disorders Type of anaemia Hemoglobin variation comment Sickle Cell Anemia Sickle haemoglobin (HbS) + Sickle haemoglobin Most Severe – No HbA Hemoglobin S-Beta thalassemia Sickle haemoglobin (HbS) + reduced HbA Mild form of Sickle Cell Disorder Hemoglobin S-C disease Sickle haemoglobin (HbS) + (HbC) Mild form of Sickle Cell Disorder Sickle Cell Trait Sickle haemoglobin (S) + Normal haemoglobin (A) Normally, humans have Of these, Haemoglobin A makes up around 96-97% of the normal haemoglobin in humans. + Recurrent episodes of painful crises, and progressive end-organ damage The American Society of Anesthesiologists© 2008, Inc.ISSN 0363-471X What is Sickle Cell Anemia (SCA)? Sickle-cell disease (SCD), or sickle-cell anaemia or drepanocytosis, is an autosomal co-dominant genetic blood disorder characterized by red blood cell that assume an abnormal, rigid, sickle shape. Sickle cell disease Dr Moutasem Almashourĭefinition Clinical Features of Sickle Cell Disease Pathophysiology Distribution of the sickle-cell(Epidemiology) Mortality/Morbidity Features of sickle-cell disease Factors That Can Cause Sickle Cell Crises Anesthetic Management Preoperative Preparation Transfusion Predictors of Postoperative SCD complications
0 Comments
Leave a Reply. |